REU students learn how to express, purify, and assay enzymes. Eric Dodds Chemistry Biological mass spectrometry To learn how mass spectrometry, tandem mass spectrometry, and ion mobility spectrometry are used to study the structures of biomolecules, the student researcher will work to develop bioanalytical methods for the detailed molecular characterization of oligosaccharides and glycoconjugates. Beyond the Fenton reaction Recent research in our group Olson et al. The REU participant will explore further applications of this chemistry, including applications to non-peroxide substrates.
Below are examples of research projects within the Chemistry Summer Undergraduate Research program. These change annually based on the interests of students and faculty. Please also see chem. Each summer, we have projects that emphasize synthesis, exploration and discovery, analysis, and computation, as well as combinations of these in collaborative teams of scientists.
We encourage you to consider not only projects of interest but also those that extend and enhance your learning. Enzymes within the radical S-adenosylmethionine SAM superfamily catalyze a dazzling array of chemical transformations that proceed via free radical intermediates. This project will focus on developing methods to annotate the functions of RS enzymes catalyzing unknown reactions.
Students will learn how to generate sequence similarity and genome neighborhood networks to provide insight into function via 9 bioinformatics methods.
They will also learn molecular biological techniques, such as cloning and site directed mutagenesis and gene expression. It is well known that protein enzymes catalyze a diverse array of chemical reactions with exceptional rates and specificity.
RNA is comprised of only four similar nitrogenous heterocycles, yet it too can catalyze chemical reactions and do so with remarkable rate acceleration and specificity. The surprising discovery that RNA can catalyze reactions is relatively recent and led to the Nobel Prize in Chemistry in This project will employ interdisciplinary approaches to understand how RNA catalyzes reactions.
Students will be engaged in a combination of molecular biology, chemical kinetics, and bioanalytical techniques. In addition, there is the option to study chemical reactions that may have formed the first RNAs that were then copied to begin life. Elucidating the broad reaction profiles of iron and 2- oxo glutarate-dependent enzymes Faculty Mentors: The most exciting new directions concern several enzymes that mediate two or three distinct reaction types e.
These sequential and divergent reactivities are certain to involve dynamic repositioning of substrates within the enzyme active sites to enable different substrates, different positions on the same substrates, or different outcomes to be targeted within the same active site.
The combination of novel chemical mechanisms and active-site structural dynamics will make for rich vehicles for excited, aspiring young biochemists and biophysicists to study modern enzymology.
Trapping and spectroscopic investigation of metalloenzyme reaction intermediates Faculty Mentor: Alexey Silakov Project Description. Metalloenzymes catalyze a wide variety of difficult reactions that, in a majority of cases, require a chain of chemical transformations.
The Silakov group is interested in a novel hybrid class of metalloenzymes containing two catalytically active domains: It is hypothesized that hydrogen is heterolytically cleaved by the [Fe-Fe] hydrogenase domain to provide electrons and protons, which in turn are used by the di-iron site of rubrerythrin to reduce hydrogen peroxide to water.
This REU project will focus on understanding the interaction between the two domains by means of trapping and characterizing intermediates in the reaction.
Students will also be provided with an opportunity to perform theoretical modeling of the experimental data using EPR simulation software and perform density functional theory calculations. Dynamics of Biological Processes Project 5: RNA viruses, including Zika, Ebola, hepatitis C and poliovirus, cause a number of acute and chronic diseases.
Our insights can be leveraged towards the rational design of new anti-viral drugs and vaccines. REU students on this project will learn state-of-theart, high-dimensional NMR techniques as they pertain to understanding protein structure and dynamics.
These NMR methods will be complemented by other spectroscopic and calorimetric methods, along with other biochemical and molecular biology techniques.
Engineering new regulatory activities into enzyme catalysts Faculty Mentor: David Boehr Project Description: The Boehr lab is interested in the development and engineering of new stimulusresponsive enzyme catalysts.
Enzymes can be viewed as small-world networks of amino acid residues connected through noncovalent interactions. Using solution-state NMR methods, we have identified amino acid networks that stretch from the surface of enzymes into their active sites.
An REU student on this project will learn approaches to covalently modify proteins, protein NMR methods to identify changes to the amino acid network, and kinetic and biological methods to determine changes to enzyme function. These studies can be leveraged towards designing new biological systems for improving applications in industry and biomedical research, including the biological syntheses of new fuels and pharmaceuticals.
Probing glutathione trafficking in cell Faculty Mentor: Joseph Cotruvo Project Description: Glutathione GSH is a ubiquitous thiol-containing tripeptide present at millimolar concentrations in eukaryotes and many prokaryotes.Chemistry Summer Research Program is a week-long, chemistry immersion program that exposes students to the excitement of chemistry research.
The program will introduce basic ideas and fundamental insights of chemistry research that have allowed chemistry to play a central role in creating our modern world. American Chemical Society: Chemistry for Life.
Project SEED is a summer research program for economically disadvantaged students. If you are a junior or senior year in high school, learn how you can work alongside scientists in a research laboratory.
ACS Scholars Program. Summer Research Projects Below you will find a list of faculty that will be conducting research during the Summer of and are looking for research students.
|Undergraduate Research Projects||The projects described below are featured to: Melissa Reynolds Project Description:|
|Corporate Sponsors of the Summer Research Program||Ten non-University of Mississippi students who have completed their freshman year of college and who have not yet graduated can participate fully in the Ole Miss Physical Chemistry Research Program activities and work on a research project under the direction of a faculty advisor. Undergraduate student participants must be citizens or permanent residents of the United States or its possessions.|
Visual Text Analysis for the Digital Humanities (Eric Alexander). Research. The Chemistry department believes that high quality research opportunities are an essential component of science education.
Students are strongly encouraged to participate in both academic year and summer research experiences. Undergraduate research in chemistry is self-directed experimentation work under the guidance and supervision of a mentor or advisor. Students participate in an ongoing research project and investigate phenomena of interest to them and their advisor.
There is a broad range of research areas in the chemical sciences. This is a list of the active chemistry division funded REU sites (Sites with active NSF awards). multidisciplinary projects, professional development; research: biocomposites, drug design, drug delivery, chemosensors, Summer Undergraduate Research in Chemistry and Biochemistry at Miami University Abstract of Award.